Research

Research

The Department has also forged close links with the Centre for AIDS Programme of Research in South Africa (CAPRISA) and collaborates with them on their HIV and TB treatment trials including: SAPIT – Starting Antiretroviral Therapy at 3 Points in TB Therapy. START trial- A randomised clinical trial to asses the effects of integrated tuberculosis and HIV care on the incidence of AIDS defining conditions on mortality in participants co-infected with TB and HIV. AACTG trials – currently involved with the regulatory and protocol implementation phase of ACTG 5221. 


A self initiated study “Diagnosis of Smear Negative HIV associated Pulmonary Tuberculosis: Comparison of Swallowed Sputum Sample Obtained by an Enteric Capsular Device with Induced Sputum”: will form the basis of Dr. Sahid’s’ Masters of Medicine degree in Infectious Diseases. The major goal of this study is to evaluate a novel method of obtaining sputa in HIV positive patients with smear negative TB. Funding has been approved for this study and it is expected to begin within the next few months. 


A collaborative research endeavour entitled “Epidemiology and Immunogenetics of Immune Reconstitution Inflammatory Syndrome (IRIS)” between the Department of HIV and Genitourinary Medicine at Kings College London, Enhancing Care Initiative at UKZN and the Department of Infectious Diseases is currently in progress. This study will form the basis for a PhD for Dr. Lewis Haddow who is currently based in the Department of Infectious Diseases as Honorary Lecturer. The goal of the study is to assess the incidence, clinical spectrum, clinical presentation and risk factors for the development of IRIS in the setting of a large antiretroviral treatment rollout setting in an area with a high burden of opportunistic infections. The study is expected to extend into early 2008.